Ferroptosis induced by environmental pollutants and its health implications
Suzuki T, Hidaka T, Kumagai Y, Yamamoto M. Environmental pollutants and the immune response. Nat Immunol. 2020;21:1486–95.
Google Scholar
Wu H, Eckhardt CM, Baccarelli AA. Molecular mechanisms of environmental exposures and human disease. Nat Rev Genet. 2023;24:332–44.
Google Scholar
Pruss-Ustun A, van Deventer E, Mudu P, Campbell-Lendrum D, Vickers C, Ivanov I, et al. Environmental risks and non-communicable diseases. BMJ. 2019;364:1265.
Li T, Yu Y, Sun Z, Duan J. A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence. Part Fibre Toxicol. 2022;19:67.
Google Scholar
Wang Y, Zhong Y, Liao J, Wang G. PM2.5-related cell death patterns. Int J Med Sci. 2021;18:1024–29.
Google Scholar
Peixoto MS, de Oliveira Galvao MF, Batistuzzo de Medeiros SR. Cell death pathways of particulate matter toxicity. Chemosphere. 2017;188:32–48.
Google Scholar
Yang L, Cai X, Li R. Ferroptosis induced by pollutants: an emerging mechanism in environmental toxicology. Environ Sci Technol. 2024;58:2166–84.
Google Scholar
Zhang Y, Xie J. Ferroptosis implication in environmental-induced neurotoxicity. Sci Total Environ. 2024;934:172618.
Google Scholar
Wang X, Kong X, Feng X, Jiang DS. Effects of DNA, RNA, and protein methylation on the regulation of ferroptosis. Int J Biol Sci. 2023;19:3558–75.
Google Scholar
Chen Y, Fang ZM, Yi X, Wei X, Jiang DS. The interaction between ferroptosis and inflammatory signaling pathways. Cell Death Dis. 2023;14:205.
Google Scholar
Chen Y, Yi X, Huo B, He Y, Guo X, Zhang Z, et al. BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection. Pharm Res. 2022;177:106122.
Google Scholar
Li N, Yi X, He Y, Huo B, Chen Y, Zhang Z, et al. Targeting ferroptosis as a novel approach to alleviate aortic dissection. Int J Biol Sci. 2022;18:4118–34.
Google Scholar
Shi J, Wang QH, Wei X, Huo B, Ye JN, Yi X, et al. Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1alpha/HMOX1 axis. Mol Med. 2023;29:91.
Google Scholar
Wei X, Yi X, Zhu XH, Jiang DS. Posttranslational modifications in ferroptosis. Oxid Med Cell Longev. 2020;2020:8832043.
Google Scholar
Yang M, Luo H, Yi X, Wei X, Jiang DS. The epigenetic regulatory mechanisms of ferroptosis and its implications for biological processes and diseases. MedComm. 2023;4:e267.
Google Scholar
Chen Y, He Y, Wei X, Jiang DS. Targeting regulated cell death in aortic aneurysm and dissection therapy. Pharm Res. 2022;176:106048.
Google Scholar
Xiang Q, Yi X, Zhu XH, Wei X, Jiang DS. Regulated cell death in myocardial ischemia-reperfusion injury. Trends Endocrinol Metab. 2023;35:219–34.
Google Scholar
Stockwell BR. Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications. Cell. 2022;185:2401–21.
Google Scholar
Evstatiev R, Gasche C. Iron sensing and signalling. Gut. 2012;61:933–52.
Google Scholar
Miao R, Fang X, Zhang Y, Wei J, Zhang Y, Tian J. Iron metabolism and ferroptosis in type 2 diabetes mellitus and complications: mechanisms and therapeutic opportunities. Cell Death Dis. 2023;14:186.
Google Scholar
Ramey G, Deschemin JC, Durel B, Canonne-Hergaux F, Nicolas G, Vaulont S. Hepcidin targets ferroportin for degradation in hepatocytes. Haematologica. 2010;95:501–4.
Google Scholar
Bayir H, Dixon SJ, Tyurina YY, Kellum JA, Kagan VE. Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney. Nat Rev Nephrol. 2023;19:315–36.
Google Scholar
Kawabata H. Transferrin and transferrin receptors update. Free Radic Biol Med. 2019;133:46–54.
Google Scholar
Feng H, Schorpp K, Jin J, Yozwiak CE, Hoffstrom BG, Decker AM, et al. Transferrin receptor is a specific ferroptosis marker. Cell Rep. 2020;30:3411–23.e7.
Google Scholar
Kruszewski M. Labile iron pool: the main determinant of cellular response to oxidative stress. Mutat Res. 2003;531:81–92.
Google Scholar
Sawicki KT, De Jesus A, Ardehali H. Iron metabolism in cardiovascular disease: physiology, mechanisms, and therapeutic targets. Circ Res. 2023;132:379–96.
Google Scholar
Shesh BP, Connor JR. A novel view of ferritin in cancer. Biochim Biophys Acta Rev Cancer. 2023;1878:188917.
Google Scholar
Hou W, Xie Y, Song X, Sun X, Lotze MT, Zeh HJ, et al. Autophagy promotes ferroptosis by degradation of ferritin. Autophagy. 2016;12:1425–8.
Google Scholar
Gao M, Monian P, Pan Q, Zhang W, Xiang J, Jiang X. Ferroptosis is an autophagic cell death process. Cell Res. 2016;26:1021–32.
Google Scholar
Wu H, Liu Q, Shan X, Gao W, Chen Q. ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4. Autophagy. 2023;19:2062–77.
Google Scholar
Wang CY, Babitt JL. Liver iron sensing and body iron homeostasis. Blood. 2019;133:18–29.
Google Scholar
Sekhar KR, Hanna DN, Cyr S, Baechle JJ, Kuravi S, Balusu R, et al. Glutathione peroxidase 4 inhibition induces ferroptosis and mTOR pathway suppression in thyroid cancer. Sci Rep. 2022;12:19396.
Google Scholar
Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156:317–31.
Google Scholar
Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, et al. Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis. Cell. 2018;172:409–22.e21.
Google Scholar
Wu Z, Geng Y, Lu X, Shi Y, Wu G, Zhang M, et al. Chaperone-mediated autophagy is involved in the execution of ferroptosis. Proc Natl Acad Sci USA. 2019;116:2996–3005.
Google Scholar
Xue Q, Yan D, Chen X, Li X, Kang R, Klionsky DJ, et al. Copper-dependent autophagic degradation of GPX4 drives ferroptosis. Autophagy. 2023;19:1982–96.
Google Scholar
Sun J, Lin XM, Lu DH, Wang M, Li K, Li SR, et al. Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. J Clin Investig. 2023;133:e165228.
Google Scholar
Ding Y, Chen X, Liu C, Ge W, Wang Q, Hao X, et al. Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells. J Hematol Oncol. 2021;14:19.
Google Scholar
Stipanuk MH, Dominy JE Jr, Lee JI, Coloso RM. Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism. J Nutr. 2006;136:1652S–59S.
Google Scholar
Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, et al. Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science. 2020;368:85–89.
Google Scholar
Swanda RV, Ji Q, Wu X, Yan J, Dong L, Mao Y, et al. Lysosomal cystine governs ferroptosis sensitivity in cancer via cysteine stress response. Mol Cell. 2023;83:3347–59.e9.
Google Scholar
Adelmann CH, Traunbauer AK, Chen B, Condon KJ, Chan SH, Kunchok T, et al. MFSD12 mediates the import of cysteine into melanosomes and lysosomes. Nature. 2020;588:699–704.
Google Scholar
Gahl WA, Thoene JG, Schneider JA. Cystinosis. N Engl J Med. 2002;347:111–21.
Google Scholar
Kang YP, Mockabee-Macias A, Jiang C, Falzone A, Prieto-Farigua N, Stone E, et al. Non-canonical glutamate-cysteine ligase activity protects against ferroptosis. Cell Metab. 2021;33:174–89.e7.
Google Scholar
Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019;575:688–92.
Google Scholar
Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature. 2019;575:693–98.
Google Scholar
Gong J, Liu Y, Wang W, He R, Xia Q, Chen L, et al. TRIM21-promoted FSP1 plasma membrane translocation confers ferroptosis resistance in human cancers. Adv Sci. 2023;10:e2302318.
Google Scholar
Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, et al. A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Nature. 2022;608:778–83.
Google Scholar
Nakamura T, Hipp C, Santos Dias Mourao A, Borggrafe J, Aldrovandi M, Henkelmann B, et al. Phase separation of FSP1 promotes ferroptosis. Nature. 2023;619:371–77.
Google Scholar
Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021;593:586–90.
Google Scholar
Mishima E, Nakamura T, Zheng J, Zhang W, Mourao ASD, Sennhenn P, et al. DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition. Nature. 2023;619:E9–E18.
Google Scholar
Qiu B, Zandkarimi F, Bezjian CT, Reznik E, Soni RK, Gu W, et al. Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis. Cell. 2024;187:1177–90.e18.
Google Scholar
Yang WS, Kim KJ, Gaschler MM, Patel M, Shchepinov MS, Stockwell BR. Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc Natl Acad Sci USA. 2016;113:E4966–75.
Google Scholar
Lee JY, Nam M, Son HY, Hyun K, Jang SY, Kim JW, et al. Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer. Proc Natl Acad Sci USA. 2020;117:32433–42.
Google Scholar
Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 2017;13:91–98.
Google Scholar
Minami JK, Morrow D, Bayley NA, Fernandez EG, Salinas JJ, Tse C, et al. CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis. Cancer Cell. 2023;41:1048–60.e9.
Google Scholar
von Krusenstiern AN, Robson RN, Qian N, Qiu B, Hu F, Reznik E, et al. Identification of essential sites of lipid peroxidation in ferroptosis. Nat Chem Biol. 2023;19:719–30.
Google Scholar
Liu W, Chakraborty B, Safi R, Kazmin D, Chang CY, McDonnell DP. Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer. Nat Commun. 2021;12:5103.
Google Scholar
Cui W, Liu D, Gu W, Chu B. Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis. Cell Death Differ. 2021;28:2536–51.
Google Scholar
Li Y, Ran Q, Duan Q, Jin J, Wang Y, Yu L, et al. 7-Dehydrocholesterol dictates ferroptosis sensitivity. Nature. 2024;626:411–18.
Google Scholar
Freitas FP, Alborzinia H, Dos Santos AF, Nepachalovich P, Pedrera L, Zilka O, et al. 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis. Nature. 2024;626:401–10.
Google Scholar
Lee H, Zandkarimi F, Zhang Y, Meena JK, Kim J, Zhuang L, et al. Energy-stress-mediated AMPK activation inhibits ferroptosis. Nat Cell Biol. 2020;22:225–34.
Google Scholar
Wu J, Minikes AM, Gao M, Bian H, Li Y, Stockwell BR, et al. Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling. Nature. 2019;572:402–06.
Google Scholar
Altman MC, Kattan M, O’Connor GT, Murphy RC, Whalen E, LeBeau P, et al. Associations between outdoor air pollutants and non-viral asthma exacerbations and airway inflammatory responses in children and adolescents living in urban areas in the USA: a retrospective secondary analysis. Lancet Planet Health. 2023;7:e33–e44.
Google Scholar
Ryu YS, Kang KA, Piao MJ, Ahn MJ, Yi JM, Bossis G, et al. Particulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications. Exp Mol Med. 2019;51:1–14.
Google Scholar
Wang X, Wang Y, Huang D, Shi S, Pei C, Wu Y, et al. Astragaloside IV regulates the ferroptosis signaling pathway via the Nrf2/SLC7A11/GPX4 axis to inhibit PM2.5-mediated lung injury in mice. Int Immunopharmacol. 2022;112:109186.
Google Scholar
Yan K, Hou T, Zhu L, Ci X, Peng L. PM2.5 inhibits system Xc- activity to induce ferroptosis by activating the AMPK-Beclin1 pathway in acute lung injury. Ecotoxicol Environ Saf. 2022;245:114083.
Google Scholar
Wang Y, Duan H, Zhang J, Wang Q, Peng T, Ye X, et al. YAP1 protects against PM2.5-induced lung toxicity by suppressing pyroptosis and ferroptosis. Ecotoxicol Environ Saf. 2023;253:114708.
Google Scholar
Yue D, Zhang Q, Zhang J, Liu W, Chen L, Wang M, et al. Diesel exhaust PM2.5 greatly deteriorates fibrosis process in pre-existing pulmonary fibrosis via ferroptosis. Environ Int. 2023;171:107706.
Google Scholar
Li N, Xiong R, Li G, Wang B, Geng Q. PM2.5 contributed to pulmonary epithelial senescence and ferroptosis by regulating USP3-SIRT3-P53 axis. Free Radic Biol Med. 2023;205:291–304.
Google Scholar
Dong T, Fan X, Zheng N, Yan K, Hou T, Peng L, et al. Activation of Nrf2 signalling pathway by tectoridin protects against ferroptosis in particulate matter-induced lung injury. Br J Pharm. 2023;180:2532–49.
Google Scholar
Guohua F, Tieyuan Z, Xinping M, Juan X. Melatonin protects against PM2.5-induced lung injury by inhibiting ferroptosis of lung epithelial cells in a Nrf2-dependent manner. Ecotoxicol Environ Saf. 2021;223:112588.
Google Scholar
Wang Y, Zhao S, Jia N, Shen Z, Huang D, Wang X, et al. Pretreatment with rosavin attenuates PM2.5-induced lung injury in rats through antiferroptosis via PI3K/Akt/Nrf2 signaling pathway. Phytother Res. 2023;37:195–210.
Google Scholar
Wang Y, Shen Z, Zhao S, Huang D, Wang X, Wu Y, et al. Sipeimine ameliorates PM2.5-induced lung injury by inhibiting ferroptosis via the PI3K/Akt/Nrf2 pathway: a network pharmacology approach. Ecotoxicol Environ Saf. 2022;239:113615.
Google Scholar
Yin B, Ren J, Cui Q, Liu X, Wang Z, Pei H, et al. Astaxanthin alleviates fine particulate matter (PM(2.5))-induced lung injury in rats by suppressing ferroptosis and apoptosis. Food Funct. 2023;14:10841–54.
Google Scholar
Zhang Y, Jiang M, Xiong Y, Zhang L, Xiong A, Wang J, et al. Integrated analysis of ATAC-seq and RNA-seq unveils the role of ferroptosis in PM2.5-induced asthma exacerbation. Int Immunopharmacol. 2023;125:111209.
Google Scholar
Zhang S, Routledge MN. The contribution of PM(2.5) to cardiovascular disease in China. Environ Sci Pollut Res Int. 2020;27:37502–13.
Google Scholar
Ren J, Yin B, Guo Z, Sun X, Pei H, Wen R, et al. Astaxanthin alleviates PM(2.5)-induced cardiomyocyte injury via inhibiting ferroptosis. Cell Mol Biol Lett. 2023;28:95.
Google Scholar
Ren JY, Yin BW, Li X, Zhu SQ, Deng JL, Sun YT, et al. Sesamin attenuates PM(2.5)-induced cardiovascular injury by inhibiting ferroptosis in rats. Food Funct. 2021;12:12671–82.
Google Scholar
Hu H, Li L, Zhang H, Zhang Y, Liu Q, Chen M, et al. Mechanism of YY1 mediating autophagy-dependent ferroptosis in PM2.5 induced cardiac fibrosis. Chemosphere. 2023;315:137749.
Google Scholar
Tanner JP, Salemi JL, Stuart AL, Yu H, Jordan MM, DuClos C, et al. Associations between exposure to ambient benzene and PM(2.5) during pregnancy and the risk of selected birth defects in offspring. Environ Res. 2015;142:345–53.
Google Scholar
Shi F, Zhang Z, Cui H, Wang J, Wang Y, Tang Y, et al. Analysis by transcriptomics and metabolomics for the proliferation inhibition and dysfunction through redox imbalance-mediated DNA damage response and ferroptosis in male reproduction of mice and TM4 Sertoli cells exposed to PM(2.5). Ecotoxicol Environ Saf. 2022;238:113569.
Google Scholar
Wang L, Luo D, Liu X, Zhu J, Wang F, Li B, et al. Effects of PM(2.5) exposure on reproductive system and its mechanisms. Chemosphere. 2021;264:128436.
Google Scholar
Carre J, Gatimel N, Moreau J, Parinaud J, Leandri R. Does air pollution play a role in infertility?: a systematic review. Environ Health. 2017;16:82.
Google Scholar
Li L, Pei Z, Wu R, Zhang Y, Pang Y, Hu H, et al. FDX1 regulates leydig cell ferroptosis mediates PM(2.5)-induced testicular dysfunction of mice. Ecotoxicol Environ Saf. 2023;263:115309.
Google Scholar
Wang J, Zhang Z, Shi F, Li Y, Tang Y, Liu C, et al. PM(2.5) caused ferroptosis in spermatocyte via overloading iron and disrupting redox homeostasis. Sci Total Environ. 2023;872:162089.
Google Scholar
Liu X, Ai Y, Xiao M, Wang C, Shu Z, Yin J, et al. PM 2.5 Juvenile exposure-induced spermatogenesis dysfunction by triggering testes ferroptosis and antioxidative vitamins intervention in adult male rats. Environ Sci Pollut Res Int. 2023;30:111051–61.
Google Scholar
Yu S, Mu Y, Wang K, Wang L, Wang C, Yang Z, et al. Gestational exposure to 1-NP induces ferroptosis in placental trophoblasts via CYP1B1/ERK signaling pathway leading to fetal growth restriction. Chem Biol Interact. 2024;387:110812.
Google Scholar
Costa LG, Cole TB, Dao K, Chang YC, Coburn J, Garrick JM. Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders. Pharm Ther. 2020;210:107523.
Google Scholar
Xiong Q, Tian X, Xu C, Ma B, Liu W, Sun B, et al. PM(2) (.5) exposure-induced ferroptosis in neuronal cells via inhibiting ERK/CREB pathway. Environ Toxicol. 2022;37:2201–13.
Google Scholar
Guo C, Lyu Y, Xia S, Ren X, Li Z, Tian F, et al. Organic extracts in PM2.5 are the major triggers to induce ferroptosis in SH-SY5Y cells. Ecotoxicol Environ Saf. 2023;249:114350.
Google Scholar
Mei H, Wu D, Yong Z, Cao Y, Chang Y, Liang J, et al. PM(2.5) exposure exacerbates seizure symptoms and cognitive dysfunction by disrupting iron metabolism and the Nrf2-mediated ferroptosis pathway. Sci Total Environ. 2024;910:168578.
Google Scholar
Wei M, Bao G, Li S, Yang Z, Cheng C, Le W. PM2.5 exposure triggers cell death through lysosomal membrane permeabilization and leads to ferroptosis insensitivity via the autophagy dysfunction/p62-KEAP1-NRF2 activation in neuronal cells. Ecotoxicol Environ Saf. 2022;248:114333.
Google Scholar
Gu W, Hou T, Zhou H, Zhu L, Zhu W, Wang Y. Ferroptosis is involved in PM2.5-induced acute nasal epithelial injury via AMPK-mediated autophagy. Int Immunopharmacol. 2023;115:109658.
Google Scholar
Gu Y, Hao S, Liu K, Gao M, Lu B, Sheng F, et al. Airborne fine particulate matter (PM(2.5)) damages the inner blood-retinal barrier by inducing inflammation and ferroptosis in retinal vascular endothelial cells. Sci Total Environ. 2022;838:156563.
Google Scholar
Park M, Cho YL, Choi Y, Min JK, Park YJ, Yoon SJ, et al. Particulate matter induces ferroptosis by accumulating iron and dysregulating the antioxidant system. BMB Rep. 2023;56:96–101.
Google Scholar
Yin K, Wang D, Zhao H, Wang Y, Zhang Y, Liu Y, et al. Polystyrene microplastics up-regulates liver glutamine and glutamate synthesis and promotes autophagy-dependent ferroptosis and apoptosis in the cerebellum through the liver-brain axis. Environ Pollut. 2022;307:119449.
Google Scholar
Sun J, Wang Y, Du Y, Zhang W, Liu Z, Bai J, et al. Involvement of the JNK/HO‑1/FTH1 signaling pathway in nanoplastic‑induced inflammation and ferroptosis of BV2 microglia cells. Int J Mol Med. 2023;52:61.
Google Scholar
Tang J, Bu W, Hu W, Zhao Z, Liu L, Luo C, et al. Ferroptosis Is involved in sex-specific small intestinal toxicity in the offspring of adult mice exposed to polystyrene nanoplastics during pregnancy. ACS Nano. 2023;17:2440–49.
Google Scholar
Chen Q, Cao Y, Li H, Liu H, Liu Y, Bi L, et al. Sodium nitroprusside alleviates nanoplastics-induced developmental toxicity by suppressing apoptosis, ferroptosis and inflammation. J Environ Manag. 2023;345:118702.
Google Scholar
Li L, Sun S, Tan L, Wang Y, Wang L, Zhang Z, et al. Polystyrene nanoparticles reduced ROS and inhibited ferroptosis by triggering lysosome stress and TFEB nucleus translocation in a size-dependent manner. Nano Lett. 2019;19:7781–92.
Google Scholar
Rochester JR, Bolden AL. Bisphenol S and F: a systematic review and comparison of the hormonal activity of bisphenol A substitutes. Environ Health Perspect. 2015;123:643–50.
Google Scholar
Yujiao C, Meng Z, Shanshan L, Wei W, Yipeng W, Chenghong Y. Exposure to bisphenol A induces abnormal fetal heart development by promoting ferroptosis. Ecotoxicol Environ Saf. 2023;255:114753.
Google Scholar
He W, Gao Z, Liu S, Tan L, Wu Y, Liu J, et al. G protein-coupled estrogen receptor activation by bisphenol-A disrupts lipid metabolism and induces ferroptosis in the liver. Environ Pollut. 2023;334:122211.
Google Scholar
Bao L, Zhao C, Feng L, Zhao Y, Duan S, Qiu M, et al. Ferritinophagy is involved in Bisphenol A-induced ferroptosis of renal tubular epithelial cells through the activation of the AMPK-mTOR-ULK1 pathway. Food Chem Toxicol. 2022;163:112909.
Google Scholar
Fang K, Li Y, Zhang Y, Liang S, Li S, Liu D. Comprehensive analysis based in silico study of alternative bisphenols – Environmental explanation of prostate cancer progression. Toxicology. 2022;465:153051.
Google Scholar
Han D, Yao Y, Chen L, Miao Z, Xu S. Apigenin ameliorates di(2-ethylhexyl) phthalate-induced ferroptosis: the activation of glutathione peroxidase 4 and suppression of iron intake. Food Chem Toxicol. 2022;164:113089.
Google Scholar
Radke EG, Braun JM, Nachman RM, Cooper GS. Phthalate exposure and neurodevelopment: a systematic review and meta-analysis of human epidemiological evidence. Environ Int. 2020;137:105408.
Google Scholar
Wang JX, Zhao Y, Chen MS, Zhang H, Cui JG, Li JL. Heme-oxygenase-1 as a target for phthalate-induced cardiomyocytes ferroptosis. Environ Pollut. 2023;317:120717.
Google Scholar
Li Y, Yan B, Wu Y, Peng Q, Wei Y, Chen Y, et al. Ferroptosis participates in dibutyl phthalate-aggravated allergic asthma in ovalbumin-sensitized mice. Ecotoxicol Environ Saf. 2023;256:114848.
Google Scholar
Wang X, He W, Wu X, Song X, Yang X, Zhang G, et al. Exposure to volatile organic compounds is a risk factor for diabetes: a cross-sectional study. Chemosphere. 2023;338:139424.
Google Scholar
Wei C, Cao L, Zhou Y, Zhang W, Zhang P, Wang M, et al. Multiple statistical models reveal specific volatile organic compounds affect sex hormones in American adult male: NHANES 2013-2016. Front Endocrinol. 2022;13:1076664.
Google Scholar
Yan M, Zhu H, Luo H, Zhang T, Sun H, Kannan K. Daily exposure to environmental volatile organic compounds triggers oxidative damage: evidence from a large-scale survey in China. Environ Sci Technol. 2023;57:20501–09.
Google Scholar
He Y, Wang X, Chen S, Luo H, Huo B, Guo X, et al. SP2509 functions as a novel ferroptosis inhibitor by reducing intracellular iron level in vascular smooth muscle cells. Free Radic Biol Med. 2024;219:49–63.
Google Scholar
Zhang W, Wang J, Liu Z, Zhang L, Jing J, Han L, et al. Iron-dependent ferroptosis participated in benzene-induced anemia of inflammation through IRP1-DHODH-ALOX12 axis. Free Radic Biol Med. 2022;193:122–33.
Google Scholar
Sun R, Liu M, Xu K, Pu Y, Huang J, Liu J, et al. Ferroptosis is involved in the benzene-induced hematotoxicity in mice via iron metabolism, oxidative stress, and NRF2 signaling pathway. Chem Biol Interact. 2022;362:110004.
Google Scholar
Tang YH, Wu L, Huang HL, Zhang PP, Zou W, Tang XQ, et al. Hydrogen sulfide antagonizes formaldehyde-induced ferroptosis via preventing ferritinophagy by upregulation of GDF11 in HT22 cells. Toxicology. 2023;491:153517.
Google Scholar
Zhang X, Jiang L, Chen H, Wei S, Yao K, Sun X, et al. Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress-related PERK pathway in MIN6 cells. Toxicology. 2022;465:153048.
Google Scholar
Cui J, Zhou Q, Yu M, Liu Y, Teng X, Gu X. 4-tert-butylphenol triggers common carp hepatocytes ferroptosis via oxidative stress, iron overload, SLC7A11/GSH/GPX4 axis, and ATF4/HSPA5/GPX4 axis. Ecotoxicol Environ Saf. 2022;242:113944.
Google Scholar
Zhang Y, Yang Y, Chen W, Mi C, Xu X, Shen Y, et al. BaP/BPDE suppressed endothelial cell angiogenesis to induce miscarriage by promoting MARCHF1/GPX4-mediated ferroptosis. Environ Int. 2023;180:108237.
Google Scholar
Huang Y, Liu X, Feng Y, Nie X, Liu Q, Du X, et al. Rotenone, an environmental toxin, causes abnormal methylation of the mouse brain organoid’s genome and ferroptosis. Int J Med Sci. 2022;19:1184–97.
Google Scholar
Fan S, Lin L, Li P, Tian H, Shen J, Zhou L, et al. Selenomethionine protects the liver from dietary deoxynivalenol exposure via Nrf2/PPARgamma-GPX4-ferroptosis pathway in mice. Toxicology. 2024;501:153689.
Google Scholar
Li SC, Gu LH, Wang YF, Wang LM, Chen L, Giesy JP, et al. A proteomic study on gastric impairment in rats caused by microcystin-LR. Sci Total Environ. 2024;917:169306.
Google Scholar
Luan P, Sun Y, Zhu Y, Qiao S, Hu G, Liu Q, et al. Cadmium exposure promotes activation of cerebrum and cerebellum ferroptosis and necrosis in swine. Ecotoxicol Environ Saf. 2021;224:112650.
Google Scholar
Qiu W, Ye J, Su Y, Zhang X, Pang X, Liao J, et al. Co-exposure to environmentally relevant concentrations of cadmium and polystyrene nanoplastics induced oxidative stress, ferroptosis, and excessive mitophagy in mice kidney. Environ Pollut. 2023;333:121947.
Google Scholar
Wang Y, Wu J, Zhang M, OuYang H, Li M, Jia D, et al. Cadmium exposure during puberty damages testicular development and spermatogenesis via ferroptosis caused by intracellular iron overload and oxidative stress in mice. Environ Pollut. 2023;325:121434.
Google Scholar
Deng P, Li J, Lu Y, Hao R, He M, Li M, et al. Chronic cadmium exposure triggered ferroptosis by perturbing the STEAP3-mediated glutathione redox balance linked to altered metabolomic signatures in humans. Sci Total Environ. 2023;905:167039.
Google Scholar
Song X, Zhuang W, Cui H, Liu M, Gao T, Li A, et al. Interactions of microplastics with organic, inorganic, and bio-pollutants and the ecotoxicological effects on terrestrial and aquatic organisms. Sci Total Environ. 2022;838:156068.
Google Scholar
Zhang Q, Xia W, Zhou X, Yang C, Lu Z, Wu S, et al. PS-MPs or their co-exposure with cadmium impair male reproductive function through the miR-199a-5p/HIF-1alpha-mediated ferroptosis pathway. Environ Pollut. 2023;339:122723.
Google Scholar
Lan Y, Hu L, Feng X, Wang M, Yuan H, Xu H. Synergistic effect of PS-MPs and Cd on male reproductive toxicity: ferroptosis via Keap1-Nrf2 pathway. J Hazard Mater. 2024;461:132584.
Google Scholar
Yu S, Li Z, Zhang Q, Wang R, Zhao Z, Ding W, et al. GPX4 degradation via chaperone-mediated autophagy contributes to antimony-triggered neuronal ferroptosis. Ecotoxicol Environ Saf. 2022;234:113413.
Google Scholar
Shi J, Ma C, Zheng Z, Zhang T, Li Z, Sun X, et al. Low-dose antimony exposure promotes prostate cancer proliferation by inhibiting ferroptosis via activation of the Nrf2-SLC7A11-GPX4 pathway. Chemosphere. 2023;339:139716.
Google Scholar
Xu Y, Zeng Q, Zhang A. Assessing the mechanisms and adjunctive therapy for arsenic-induced liver injury in rats. Environ Toxicol. 2024;39:1197–209.
Google Scholar
Yang D, Xia X, Xi S. Salvianolic acid A attenuates arsenic-induced ferroptosis and kidney injury via HIF-2alpha/DUOX1/GPX4 and iron homeostasis. Sci Total Environ. 2024;907:168073.
Google Scholar
Wang Z, Li K, Xu Y, Song Z, Lan X, Pan C, et al. Ferroptosis contributes to nickel-induced developmental neurotoxicity in zebrafish. Sci Total Environ. 2023;858:160078.
Google Scholar
Frush DP, Perez MDR. Children, medical radiation and the environment: an important dialogue. Environ Res. 2017;156:358–63.
Google Scholar
Yang P, Li J, Zhang T, Ren Y, Zhang Q, Liu R, et al. Ionizing radiation-induced mitophagy promotes ferroptosis by increasing intracellular free fatty acids. Cell Death Differ. 2023;30:2432–45.
Google Scholar
Gao Y, Chen B, Wang R, Xu A, Wu L, Lu H, et al. Knockdown of RRM1 in tumor cells promotes radio-/chemotherapy-induced ferroptosis by regulating p53 ubiquitination and p21-GPX4 signaling axis. Cell Death Discov. 2022;8:343.
Google Scholar
Zheng Z, Shang X, Sun K, Hou Y, Zhang X, Xu J, et al. P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability. Free Radic Biol Med. 2024;212:336–48.
Google Scholar
Ho IK, Cash BD, Cohen H, Hanauer SB, Inkster M, Johnson DA, et al. Radiation exposure in gastroenterology: improving patient and staff protection. Am J Gastroenterol. 2014;109:1180–94.
Google Scholar
Tapio S, Little MP, Kaiser JC, Impens N, Hamada N, Georgakilas AG, et al. Ionizing radiation-induced circulatory and metabolic diseases. Environ Int. 2021;146:106235.
Google Scholar
Wu S, Tian C, Tu Z, Guo J, Xu F, Qin W, et al. Protective effect of total flavonoids of Engelhardia roxburghiana Wall. leaves against radiation-induced intestinal injury in mice and its mechanism. J Ethnopharmacol. 2023;311:116428.
Google Scholar
Kong P, Yang M, Wang Y, Yu KN, Wu L, Han W. Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in radiation-induced intestinal injury. Redox Biol. 2023;66:102857.
Google Scholar
Zhang F, Liu T, Huang HC, Zhao YY, He M, Yuan W, et al. Activation of pyroptosis and ferroptosis is involved in radiation-induced intestinal injury in mice. Biochem Biophys Res Commun. 2022;631:102–09.
Google Scholar
Wang L, Wang A, Fu Q, Shi Z, Chen X, Wang Y, et al. Ferroptosis plays an important role in promoting ionizing radiation-induced intestinal injuries. Biochem Biophys Res Commun. 2022;595:7–13.
Google Scholar
Dar HH, Epperly MW, Tyurin VA, Amoscato AA, Anthonymuthu TS, Souryavong AB, et al. P. aeruginosa augments irradiation injury via 15-lipoxygenase-catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis. JCI Insight. 2022;7:e156013.
Google Scholar
Zhang X, Tian M, Li X, Zheng C, Wang A, Feng J, et al. Hematopoietic protection and mechanisms of ferrostatin-1 on hematopoietic acute radiation syndrome of mice. Int J Radiat Biol. 2021;97:464–73.
Google Scholar
Wu Z, Chen T, Qian Y, Luo G, Liao F, He X, et al. High-dose ionizing radiation accelerates atherosclerotic plaque progression by regulating P38/NCOA4-mediated ferritinophagy/ferroptosis of endothelial cells. Int J Radiat Oncol Biol Phys. 2023;117:223–36.
Google Scholar
Farzipour S, Jalali F, Alvandi M, Shaghaghi Z. Ferroptosis inhibitors as new therapeutic insights into radiation-induced heart disease. Cardiovasc Hematol Agents Med Chem. 2023;21:2–9.
Google Scholar
Li X, Zhuang X, Qiao T. Role of ferroptosis in the process of acute radiation-induced lung injury in mice. Biochem Biophys Res Commun. 2019;519:240–45.
Google Scholar
Li X, Chen J, Yuan S, Zhuang X, Qiao T. Activation of the P62-Keap1-NRF2 pathway protects against ferroptosis in radiation-induced lung injury. Oxid Med Cell Longev. 2022;2022:8973509.
Google Scholar
Liu T, Yang Q, Zheng H, Jia H, He Y, Zhang X, et al. Multifaceted roles of a bioengineered nanoreactor in repressing radiation-induced lung injury. Biomaterials. 2021;277:121103.
Google Scholar
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